Listar por autor "Moriyón Uría, Ignacio"
Mostrando ítems 1-8 de 8
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Brucella abortus ornithine lipids are dispensable outer membrane components devoid of a marked pathogen-associated molecular pattern
Palacios Chaves, Leyre; Conde Álvarez, Raquel; Gil Ramírez, Yolanda ; Zúñiga Ripa, Amaia; Barquero-Calvo, Elías; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moreno, Edgardo; Miguel, María Jesús de; Grilló Dolset, María Jesús; Moriyón Uría, Ignacio; Iriarte, Maite (Public Library of Science, 2011) Artículo / ArtikuluaThe brucellae are alpha-Proteobacteria facultative intracellular parasites that cause an important zoonosis. These bacteria escape early detection by innate immunity, an ability associated to the absence of marked ... -
Brucellosis vaccines: assessment of brucella melitensis lipopolysaccharide rough mutants defective in core and O-polysaccharide synthesis and export
González, David; Grilló Dolset, María Jesús; Miguel, María Jesús de; Ali, Tara; Arce Gorvel, Vilma; Delrue, Rose May; Conde Álvarez, Raquel; Muñoz Álvaro, Pilar María; López Goñi, Ignacio; Iriarte, Maite; Marín, Clara M.; Weintraub, Andrej; Widmalm, Goeran; Zygmunt, Michel; Letesson, Jean-Jacques; Gorvel, Jean-Pierre; Blasco, José María ; Moriyón Uría, Ignacio (Public Library of Science, 2008) Artículo / ArtikuluaBackground: The brucellae are facultative intracellular bacteria that cause brucellosis, one of the major neglected zoonoses. In endemic areas, vaccination is the only effective way to control this disease. Brucella ... -
BvrR/BvrS-controlled outer membrane proteins Omp3a and Omp3b are not essential for Brucella abortus virulence
Manterola, Lorea; Guzman-Verri, Caterina; Chaves Olarte, Esteban; Barquero-Calvo, Elías; Miguel, María Jesús de; Moriyón Uría, Ignacio; Grilló Dolset, María Jesús; López Goñi, Ignacio; Moreno, Edgardo (American Society for Microbiology, 2007) Artículo / ArtikuluaThe Brucella abortus two-component regulatory system BvrR/BvrS controls the expression of outer membrane proteins (Omp) Omp3a (Omp25) and Omp3b (Omp22). Disruption of bvrS or bvrR generates avirulent mutants with altered ... -
Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine
Mancilla, Marcos; Grilló Dolset, María Jesús; Miguel López, María Jesús de; López Goñi, Ignacio; San Román Aberasturi, Beatriz ; Zabalza Baranguá, Ana ; Moriyón Uría, Ignacio (BioMed Central, 2013) Artículo / ArtikuluaBrucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation ... -
Identification of lptA, lpxE, and lpxO, three genes involved in the remodeling of Brucella cell envelope
Conde Álvarez, Raquel; Palacios Chaves, Leyre; Gil Ramírez, Yolanda ; Salvador Bescós, Miriam; Bárcena-Varela, Marina; Aragón Aranda, Beatriz; Martínez Gómez, Estrella; Zúñiga Ripa, Amaia; Miguel López, María Jesús de; Bartholomew, Toby Leigh; Hanniffy, Sean; Grilló Dolset, María Jesús; Vences Guzmán, Miguel Ángel; Bengoechea Alonso, José Antonio; Arce Gorvel, Vilma; Gorvel, Jean-Pierre; Moriyón Uría, Ignacio; Iriarte, Maite (Frontiers Media, 2018) Artículo / ArtikuluaThe brucellae are facultative intracellular bacteria that cause a worldwide extended zoonosis. One of the pathogenicity mechanisms of these bacteria is their ability to avoid rapid recognition by innate immunity because ... -
The lipopolysaccharide core of Brucella abortus acts as a shield against innate immunity recognition
Conde Álvarez, Raquel; Bargen, Kristine von; Grilló Dolset, María Jesús; Jerala, Roman; Brandenburg, Klaus; Llobet, Enrique; Bengoechea Alonso, José Antonio; Moreno, Edgardo; Moriyón Uría, Ignacio; Gorvel, Jean-Pierre; Arce Gorvel, Vilma; Iriarte, Maite; Mancek Keber, Mateja; Barquero-Calvo, Elías; Palacios Chaves, Leyre; Chacón Díaz, Carlos; Chaves Olarte, Esteban; Martirosyan, Anna (Public Library of Science, 2012) Artículo / ArtikuluaInnate immunity recognizes bacterial molecules bearing pathogen-associated molecular patterns to launch inflammatory responses leading to the activation of adaptive immunity. However, the lipopolysaccharide (LPS) of the ... -
Mutants in the lipopolysaccharide of Brucella ovis are attenuated and protect against B. ovis infection in mice
Soler Lloréns, Pedro; Gil Ramírez, Yolanda ; Zabalza Baranguá, Ana ; Iriarte, Maite; Conde Álvarez, Raquel; Zúñiga Ripa, Amaia; San Román Aberasturi, Beatriz ; Zygmunt, Michel; Vizcaíno, Nieves; Cloeckaert, Axel; Grilló Dolset, María Jesús; Moriyón Uría, Ignacio; López Goñi, Ignacio (BioMed Central, 2014) Artículo / ArtikuluaBrucella spp. are Gram-negative bacteria that behave as facultative intracellular parasites of a variety of mammals. This genus includes smooth (S) and rough (R) species that carry S and R lipopolysaccharides (LPS), ... -
What have we learned from brucellosis in the mouse model?
Grilló Dolset, María Jesús; Blasco, José María ; Gorvel, Jean-Pierre; Moriyón Uría, Ignacio; Moreno, Edgardo (BioMed Central, 2012) Artículo / ArtikuluaBrucellosis is a zoonosis caused by Brucella species. Brucellosis research in natural hosts is often precluded by practical, economical and ethical reasons and mice are widely used. However, mice are not natural Brucella ...